|Application ||WB, IHC-P|
|Reactivity||Human, Monkey, Bovine|
|Dilution||IHC-P (10 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||C5a anaphylatoxin chemotactic receptor 2, Complement component 5a receptor 2, G-protein coupled receptor 77, C5AR2, C5L2, GPR77|
|Target/Specificity||A portion of amino acids 1-50 of human GPR77|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||C5AR2 / GPR77 / C5L2 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Frontal cortex, hippocampus, hypothalamus, pons and liver.|
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Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
Ohno M.,et al.Mol. Immunol. 37:407-412(2000).
Lee D.K.,et al.Brain Res. Mol. Brain Res. 86:13-22(2001).
Kopatz S.A.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
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