|Application ||WB, IHC-P|
|Reactivity||Human, Monkey, Bovine|
|Dilution||IHC-P (10 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||C5a anaphylatoxin chemotactic receptor 2, Complement component 5a receptor 2, G-protein coupled receptor 77, C5AR2, C5L2, GPR77|
|Target/Specificity||A portion of amino acids 1-50 of human GPR77|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||C5AR2 / GPR77 / C5L2 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Frontal cortex, hippocampus, hypothalamus, pons and liver.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways.
Ohno M.,et al.Mol. Immunol. 37:407-412(2000).
Lee D.K.,et al.Brain Res. Mol. Brain Res. 86:13-22(2001).
Kopatz S.A.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
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