|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Monkey, Chicken, Horse, Bovine, Dog|
|Dilution||IHC-P (10 µg/ml), WB (0.1-0.5 µg/ml),|
|Other Names||Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF, ARHGEF11, KIAA0380|
|Target/Specificity||A portion of amino acids 1-50 of human ARHGEF11|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||ARHGEF11 Antibody (aa1-50) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.|
|Cellular Location||Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation|
|Tissue Location||Ubiquitously expressed.|
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May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
Nagase T.,et al.DNA Res. 4:141-150(1997).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Ruemenapp U.,et al.FEBS Lett. 459:313-318(1999).
Fukuhara S.,et al.J. Biol. Chem. 274:5868-5879(1999).
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