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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CYP1B1 Antibody (aa200-250)   

CYP1B1 Antibody (aa200-250)

Rabbit Polyclonal Antibody

     
  • IHC - CYP1B1 Antibody (aa200-250) ALS11935
    Anti-CYP1B1 antibody IHC of human testis.
  • IHC - CYP1B1 Antibody (aa200-250) ALS11935
    Anti-CYP1B1 antibody IHC of mouse testis.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q16678
Reactivity Human, Mouse, Rat, Zebrafish, Monkey, Opossum, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 61kDa
Dilution IHC-P (10 µg/ml), WB (0.5-1 µg/ml),
Additional Information
Gene ID 1545
Other Names Cytochrome P450 1B1, 1.14.14.1, CYPIB1, CYP1B1
Target/Specificity A portion of amino acids 200-250 of human CYP1B1
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsCYP1B1 Antibody (aa200-250) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP1B1
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein Mitochondrion
Tissue Location Expressed in many tissues.
Research Areas
Citations (0)

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Background

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.

References

Sutter T.R.,et al.J. Biol. Chem. 269:13092-13099(1994).
Tang Y.M.,et al.J. Biol. Chem. 271:28324-28330(1996).
Gorry M.C.,et al.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Guillemette C.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS11935
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