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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HIPK3 / FIST Antibody (aa850-900)   

HIPK3 / FIST Antibody (aa850-900)

Rabbit Polyclonal Antibody

     
  • IHC - HIPK3 / FIST Antibody (aa850-900) ALS11936
    Anti-HIPK3 antibody IHC of human testis.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9H422
Reactivity Human, Mouse, Rat, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 134kDa
Dilution IHC-P (10 µg/ml), WB (0.5-2 µg/ml),
Additional Information
Gene ID 10114
Other Names Homeodomain-interacting protein kinase 3, 2.7.11.1, Androgen receptor-interacting nuclear protein kinase, ANPK, Fas-interacting serine/threonine-protein kinase, FIST, Homolog of protein kinase YAK1, HIPK3, DYRK6, FIST3, PKY
Target/Specificity A portion of amino acids 850-900 of human HIPK3
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsHIPK3 / FIST Antibody (aa850-900) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HIPK3
Synonyms DYRK6, FIST3, PKY
Function Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF- responsive element (OCFRE).
Cellular Location Cytoplasm. Nucleus
Tissue Location Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.
Research Areas
Citations (0)

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Background

Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF- responsive element (OCFRE).

References

Begley D.A.,et al.Gene 200:35-43(1997).
Rochat-Steiner V.,et al.J. Exp. Med. 192:1165-1174(2000).
Taylor T.D.,et al.Nature 440:497-500(2006).
Becker W.,et al.Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
Moilanen A.-M.,et al.Mol. Biol. Cell 9:2527-2543(1998).

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$ 395.00
Cat# ALS11936
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