|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Zebrafish, Monkey, Chicken, Horse, Xenopus, Bovine|
|Dilution||IHC-P (10 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Endoplasmin, 94 kDa glucose-regulated protein, GRP-94, Heat shock protein 90 kDa beta member 1, Tumor rejection antigen 1, gp96 homolog, HSP90B1, GRP94, TRA1|
|Target/Specificity||A portion of amino acids 590-640 of human GRP94|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||HSP90B1 / GP96 / GRP94 Antibody (aa590-640) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.|
|Cellular Location||Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
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Provided below are standard protocols that you may find useful for product applications.
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.
Maki R.G.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:5658-5662(1990).
Chang S.C.,et al.Mol. Cell. Biol. 9:2153-2162(1989).
Meng S.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Gevaert K.,et al.Nat. Biotechnol. 21:566-569(2003).
Meunier L.,et al.Mol. Biol. Cell 13:4456-4469(2002).
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