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UBE1L2 / UBE1L2 Antibody (aa300-350)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | A0AVT1 |
| Reactivity | Human, Mouse, Rat, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 118kDa |
| Dilution | IHC-P (10 µg/ml), WB (1-3 µg/ml), |
| Gene ID | 55236 |
|---|---|
| Other Names | Ubiquitin-like modifier-activating enzyme 6, Ubiquitin-activating enzyme 6, Monocyte protein 4, MOP-4, Ubiquitin-activating enzyme E1-like protein 2, E1-L2, UBA6, MOP4, UBE1L2 |
| Target/Specificity | A portion of amino acids 300-350 of human UBE1L2/MOP-4 |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | UBE1L2 / UBE1L2 Antibody (aa300-350) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UBA6 |
|---|---|
| Synonyms | MOP4, UBE1L2 |
| Function | Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. |
| Tissue Location | Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.
References
Zhu H.,et al.Acta Biochim. Biophys. Sin. 36:227-234(2004).
Jin J.,et al.Nature 447:1135-1138(2007).
Takayama K.,et al.Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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