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Derlin-3 / DERL3 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - Derlin-3 / DERL3 Antibody (N-Terminus) ALS11953
    Anti-DERL3 antibody IHC of human pancreas.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96Q80
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 27kDa
Dilution ELISA (1 µg/ml), IHC-P (20 µg/ml), WB (1 µg/ml)
Additional Information
Gene ID 91319
Other Names Derlin-3, Degradation in endoplasmic reticulum protein 3, DERtrin-3, Der1-like protein 3, DERL3, C22orf14, DER3, LLN2
Target/Specificity synthetic peptide corresponding to N-terminal residues of human DERL3 (Derlin-3)
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsDerlin-3 / DERL3 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DERL3
Synonyms C22orf14, DER3, LLN2
Function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine.
Research Areas
Citations (0)

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Background

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate.

References

Shimizu N.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Oda Y.,et al.J. Cell Biol. 172:383-393(2006).

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$ 395.00
Cat# ALS11953
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