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SLC15A1 / PEPT1 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - SLC15A1 / PEPT1 Antibody (C-Terminus) ALS11960
    Anti-SLC15A1 antibody IHC of human brain, cerebellum.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P46059
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 79kDa
Dilution ELISA (1 µg/ml), IHC-P (10 µg/ml), WB (1 µg/ml)
Additional Information
Gene ID 6564
Other Names Solute carrier family 15 member 1, Intestinal H(+)/peptide cotransporter, Oligopeptide transporter, small intestine isoform, Peptide transporter 1, SLC15A1, PEPT1
Target/Specificity synthetic peptide corresponding to C-terminal residues of human PEPT1 (Peptide transporter 1)
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsSLC15A1 / PEPT1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SLC15A1 (HGNC:10920)
Function Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (PubMed:7896779, PubMed:9835627, PubMed:8914574, PubMed:15521010, PubMed:18367661, PubMed:19685173, PubMed:26320580) (By similarity). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system (PubMed:9835627, PubMed:15521010).
Cellular Location Apical cell membrane; Multi-pass membrane protein. Note=Localized to the apical membrane of enterocytes
Tissue Location Expressed in small intestine.
Research Areas
Citations (0)
citation

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Background

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products.

References

Liang R.,et al.J. Biol. Chem. 270:6456-6463(1995).
Dunham A.,et al.Nature 428:522-528(2004).
Saito S.,et al.J. Hum. Genet. 47:576-584(2002).
Anderle P.,et al.J. Pharmacol. Exp. Ther. 316:636-646(2006).

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$ 467.50
Cat# ALS11960
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