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TK1 / TK / Thymidine Kinase Antibody (N-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P04183 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 25kDa |
| Dilution | ELISA (1 µg/ml), IHC-P (20 µg/ml), WB (1 µg/ml) |
| Gene ID | 7083 |
|---|---|
| Other Names | Thymidine kinase, cytosolic, 2.7.1.21, TK1 |
| Target/Specificity | synthetic peptide corresponding to N-terminal residues of human TK1 (Thymidine kinase, cytosolic) |
| Reconstitution & Storage | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Precautions | TK1 / TK / Thymidine Kinase Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TK1 (HGNC:11830) |
|---|---|
| Function | Cell-cycle-regulated enzyme of importance in nucleotide metabolism (PubMed:9575153). Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate (PubMed:22385435). Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c- azido-3c-deoxythymidine (AZT) (PubMed:22385435). |
| Cellular Location | Cytoplasm. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Bradshaw H.D. Jr.,et al.Mol. Cell. Biol. 4:2316-2320(1984).
Flemington E.,et al.Gene 52:267-277(1987).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Kreidberg J.A.,et al.Mol. Cell. Biol. 6:2903-2909(1986).
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