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Prohibitin 2 / PHB2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - Prohibitin 2 / PHB2 Antibody (C-Terminus) ALS11997
    Anti-PHB2 antibody IHC of human brain, cortex.
  • WB - Prohibitin 2 / PHB2 Antibody (C-Terminus) ALS11997
    MCF-7 whole cell extract was resolved by electrophoresis, transferred to nitrocellulose and...
  • ICC - Prohibitin 2 / PHB2 Antibody (C-Terminus) ALS11997
    Immunofluorescent microscope analysis of Hela cells using anti-BAP37 polyclonal antibody (red).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC
Primary Accession Q99623
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 33kDa
Dilution IHC-P (1:50)
Additional Information
Gene ID 11331
Other Names Prohibitin-2, B-cell receptor-associated protein BAP37, D-prohibitin, Repressor of estrogen receptor activity, PHB2 {ECO:0000312|EMBL:AAH14766.1, ECO:0000312|HGNC:HGNC:30306}
Target/Specificity Recombinant (partial), C-terminal.
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsProhibitin 2 / PHB2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PHB2 {ECO:0000312|EMBL:AAH14766.1, ECO:0000312|HGNC:HGNC:30306}
Function Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.
Cellular Location Mitochondrion inner membrane {ECO:0000250|UniProtKB:O35129}. Cytoplasm. Nucleus
Volume 50 µl
Research Areas
Citations (0)

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Background

Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

References

Ansari-Lari M.A.,et al.Genome Res. 7:268-280(1997).
Montano M.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:6947-6952(1999).
Zhang W.,et al.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
Hu R.-M.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS11997
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