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SOX2 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - SOX2 Antibody (N-Terminus) ALS12003
    Anti-SOX2 antibody IHC of human brain, cortex.
    detail
  • WB - SOX2 Antibody (N-Terminus) ALS12003
    NTERA-2 whole cell extract was resolved by electrophoresis, transferred to nitrocellulose and...
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P48431
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 34kDa
Dilution IHC-P (1:50)
Additional Information
Gene ID 6657
Other Names Transcription factor SOX-2, SOX2
Target/Specificity Peptide-KLH (N-terminal)
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsSOX2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOX2
Function Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity).
Cellular Location Nucleus speckle {ECO:0000250|UniProtKB:Q05066}. Cytoplasm {ECO:0000250|UniProtKB:Q05738}. Nucleus {ECO:0000250|UniProtKB:Q05738}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity) Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity) {ECO:0000250|UniProtKB:Q05066, ECO:0000250|UniProtKB:Q05738}
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

References

Stevanovic M.,et al.Mamm. Genome 5:640-642(1994).
Sadler L.A.,et al.Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases.
Fantes J.,et al.Nat. Genet. 33:461-463(2003).
Takahashi K.,et al.Cell 131:861-872(2007).
Rigbolt K.T.,et al.Sci. Signal. 4:RS3-RS3(2011).

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Discontinued
Cat# ALS12003
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