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TAF1 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - TAF1 Antibody ALS12007
    Anti-TAF1 antibody IHC of human breast.
  • WB - TAF1 Antibody ALS12007
    MCF7 nuclear extract was resolved by electrophoresis, transferred to nitrocellulose, and probed...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P21675
Reactivity Human, Mouse, Rat, Hamster, Monkey, Horse, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 213kDa
Dilution IHC-P (1:50)
Additional Information
Gene ID 6872
Other Names Transcription initiation factor TFIID subunit 1, 2.3.1.48, 2.7.11.1, Cell cycle gene 1 protein, TBP-associated factor 250 kDa, p250, Transcription initiation factor TFIID 250 kDa subunit, TAF(II)250, TAFII-250, TAFII250, TAF1, BA2R, CCG1, CCGS, TAF2A
Target/Specificity Peptide-KLH (QLEGESVLDDE)
Reconstitution & Storage Store at -20°C. Aliquot to avoid freeze/thaw cycles.
PrecautionsTAF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAF1
Synonyms BA2R, CCG1, CCGS, TAF2A
Function Largest component and core scaffold of the TFIID basal transcription factor complex (PubMed:25412659, PubMed:27007846). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2- mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300).
Cellular Location Nucleus
Citations (0)

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Background

Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA- binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4.

References

Sekiguchi T.,et al.Mol. Cell. Biol. 11:3317-3325(1991).
Sekiguchi T.,et al.EMBO J. 7:1683-1687(1988).
Ruppert S.,et al.Nature 362:175-179(1993).
Makino S.,et al.Am. J. Hum. Genet. 80:393-406(2007).
Ross M.T.,et al.Nature 434:325-337(2005).

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Discontinued
Cat# ALS12007
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