|Application ||WB, IHC-P|
|Other Names||Mitochondrial uncoupling protein 2, UCP 2, Solute carrier family 25 member 8, UCPH, UCP2, SLC25A8|
|Target/Specificity||Recombinant (partial), N-terminal|
|Reconstitution & Storage||+4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||UCP2 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.|
|Cellular Location||Mitochondrion inner membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed in adult human tissues, including tissues rich in macrophages. Most expressed in white adipose tissue and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Boss O.,et al.FEBS Lett. 408:39-42(1997).
Fleury C.,et al.Nat. Genet. 15:269-272(1997).
Gimeno R.E.,et al.Diabetes 46:900-906(1997).
Klannemark M.,et al.Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
Argyropoulos G.,et al.Diabetes 47:685-687(1998).
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