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NKIRAS1 Antibody (aa96-113, clone 184C278)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9NYS0 |
| Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Goat, Horse, Dog |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 184C278 |
| Calculated MW | 22kDa |
| Dilution | IHC-P (5 µg/ml), WB (0.5-1 µg/ml), |
| Gene ID | 28512 |
|---|---|
| Other Names | NF-kappa-B inhibitor-interacting Ras-like protein 1, I-kappa-B-interacting Ras-like protein 1, Kappa B-Ras protein 1, KappaB-Ras1, NKIRAS1, KBRAS1 |
| Target/Specificity | A synthetic peptide containing amino acid residues 96-113 of human kB-Ras1. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | NKIRAS1 Antibody (aa96-113, clone 184C278) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NKIRAS1 |
|---|---|
| Synonyms | KBRAS1 |
| Function | Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
References
Fenwick C.,et al.Science 287:869-873(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Chen Y.,et al.J. Biol. Chem. 278:23101-23106(2003).
Chen Y.,et al.Mol. Cell. Biol. 24:3048-3056(2004).
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