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PRDM5 Antibody (aa100-200)

Rabbit Polyclonal Antibody

     
  • WB - PRDM5 Antibody (aa100-200) ALS12041
    Western blot of PRDM5 in HL60 cell lysate using antibody at 1 ug/ml.
  • IHC - PRDM5 Antibody (aa100-200) ALS12041
    Anti-PRDM5 antibody IHC of human colon.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9NQX1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 73kDa
Dilution IHC-P (5 µg/ml), WB (1-3 µg/ml),
Additional Information
Gene ID 11107
Other Names PR domain zinc finger protein 5, 2.1.1.-, PR domain-containing protein 5, PRDM5, PFM2
Target/Specificity A portion of amino acids 100-200 of human PRDM5 protein was used as the immunogen.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsPRDM5 Antibody (aa100-200) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRDM5
Synonyms PFM2
Function Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells.
Cellular Location Nucleus
Tissue Location Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.
Citations (0)

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Background

Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells.

References

Deng Q.,et al.Oncogene 23:4903-4910(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Watanabe Y.,et al.Clin. Cancer Res. 13:4786-4794(2007).
Duan Z.,et al.Mol. Cell. Biol. 27:6889-6902(2007).

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$ 395.00
Cat# ALS12041
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