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PRDM5 Antibody (aa100-200)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q9NQX1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 73kDa |
| Dilution | IHC-P (5 µg/ml), WB (1-3 µg/ml), |
| Gene ID | 11107 |
|---|---|
| Other Names | PR domain zinc finger protein 5, 2.1.1.-, PR domain-containing protein 5, PRDM5, PFM2 |
| Target/Specificity | A portion of amino acids 100-200 of human PRDM5 protein was used as the immunogen. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | PRDM5 Antibody (aa100-200) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PRDM5 |
|---|---|
| Synonyms | PFM2 |
| Function | Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells. |
| Cellular Location | Nucleus |
| Tissue Location | Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells.
References
Deng Q.,et al.Oncogene 23:4903-4910(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Watanabe Y.,et al.Clin. Cancer Res. 13:4786-4794(2007).
Duan Z.,et al.Mol. Cell. Biol. 27:6889-6902(2007).
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