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>   home   >   Products   >   Primary Antibodies   >   PRMT7 Antibody (aa346-360)   

PRMT7 Antibody (aa346-360)

Rabbit Polyclonal Antibody

     
  • WB - PRMT7 Antibody (aa346-360) ALS12042
    Western blot of PRMT7 in (A) HeLa and (B)?NIH 3T3?cell lysate using antibody at 0.5 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9NVM4
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 78kDa
Dilution IHC-P (10 µg/ml), WB (1-3 µg/ml),
Additional Information
Gene ID 54496
Other Names Protein arginine N-methyltransferase 7, 2.1.1.-, Histone-arginine N-methyltransferase PRMT7, 2.1.1.125, [Myelin basic protein]-arginine N-methyltransferase PRMT7, 2.1.1.126, PRMT7, KIAA1933
Target/Specificity Amino acids 346-360 of human PRMT7 were used as the immunogen.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsPRMT7 Antibody (aa346-360) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRMT7
Synonyms KIAA1933
Function Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
Cellular Location Cytoplasm, cytosol. Nucleus
Volume 50 µl
Citations (0)

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Background

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nagase T.,et al.DNA Res. 8:179-187(2001).
Miranda T.B.,et al.J. Biol. Chem. 279:22902-22907(2004).
Lee J.-H.,et al.J. Biol. Chem. 280:3656-3664(2005).
Gonsalvez G.B.,et al.J. Cell Biol. 178:733-740(2007).

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$ 395.00
Cat# ALS12042
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