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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GCN2 Antibody   

GCN2 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - GCN2 Antibody ALS12046
    Anti-EIF2AK4 / GCN2 antibody IHC of human brain, cortex.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9P2K8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 187kDa
Dilution IHC-P (1:50)
Additional Information
Gene ID 440275
Other Names Eukaryotic translation initiation factor 2-alpha kinase 4, 2.7.11.1, GCN2-like protein, EIF2AK4, GCN2, KIAA1338
Target/Specificity Recombinant partial protein corresponding to a. a.120-330 of human GCN2.
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsGCN2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF2AK4 (HGNC:19687)
Synonyms GCN2, KIAA1338
Function Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability (PubMed:25329545). Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF- 2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory. Plays a role in neurite outgrowth inhibition. Plays a proapoptotic role in response to glucose deprivation. Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress- activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (By similarity). Plays a role in the antiviral response against alphavirus infection; impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9QZ05}.
Tissue Location Widely expressed (PubMed:10504407). Expressed in lung, smooth muscle cells and macrophages (PubMed:24292273)
Volume 50 µl
Research Areas
Citations (0)

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Background

Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.

References

Zody M.C.,et al.Nature 440:671-675(2006).
Nagase T.,et al.DNA Res. 7:65-73(2000).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Berlanga J.J.,et al.Eur. J. Biochem. 265:754-762(1999).

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$ 395.00
Cat# ALS12046
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