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>   home   >   Products   >   Primary Antibodies   >   EIF4E Antibody (N-Terminus)   

EIF4E Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - EIF4E Antibody (N-Terminus) ALS12048
    MCF-7 cell extract was resolved by electrophoresis, transferred to nitrocellulose,and probed...
  • IHC - EIF4E Antibody (N-Terminus) ALS12048
    Anti-EIF4E antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P06730
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 25kDa
Dilution IHC-P (1:50), WB (2 µg/ml),
Additional Information
Gene ID 1977
Other Names Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein, EIF4E, EIF4EL1, EIF4F
Target/Specificity Recombinant (partial), N-terminal
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsEIF4E Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EIF4E
Synonyms EIF4EL1, EIF4F
Function Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.
Cellular Location Cytoplasm, P-body. Cytoplasm
Citations (0)

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Background

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.

References

Rychlik W.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:945-949(1987).
Rychlik W.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:1148-1148(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Oh J.H.,et al.Mamm. Genome 16:942-954(2005).

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Discontinued
Cat# ALS12048
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