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>   home   >   Products   >   Primary Antibodies   >   MCM7 Antibody (C-Terminus)   

MCM7 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • WB - MCM7 Antibody (C-Terminus) ALS12058
    Hela cell nuclear extract was resolved by electrophoresis, transferred to nitrocellulose, and...
  • IHC - MCM7 Antibody (C-Terminus) ALS12058
    Anti-MCM7 antibody IHC of human skin.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P33993
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 81kDa
Dilution IHC-P (1:50)
Additional Information
Gene ID 4176
Other Names DNA replication licensing factor MCM7, 3.6.4.12, CDC47 homolog, P1.1-MCM3, MCM7, CDC47, MCM2
Target/Specificity Recombinant, C-terminal
Reconstitution & Storage Aliquot and store at -20°C. Minimize freezing and thawing.
PrecautionsMCM7 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCM7
Synonyms CDC47, MCM2
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
Cellular Location Nucleus.
Citations (0)

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Background

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

References

Fujita M.,et al.J. Biol. Chem. 271:4349-4354(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.W.,et al.Science 300:767-772(2003).
Hillier L.W.,et al.Nature 424:157-164(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12058
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