|Application ||WB, IHC-P, Flo|
|Dilution||IHC-P (5 µg/ml), WB (1-2 µg/ml),|
|Other Names||C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein coupled receptor 2, CCR10, GPR2|
|Target/Specificity||A peptide corresponding to amino acids 350-362 of human CCR10. In this region, mouse and human amino acid sequences are 100% identical|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||CCR10 / GPR2 Antibody (aa350-362) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid and spinal cord. Also expressed by melanocytes, dermal fibroblasts, dermal microvascular endothelial cells. Also detected in T-cells and in skin-derived Langerhans cells.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
Jarmin D.I.,et al.J. Immunol. 164:3460-3464(2000).
Homey B.,et al.J. Immunol. 164:3465-3470(2000).
Kopatz S.A.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
Marchese A.,et al.Genomics 23:609-618(1994).
Wang W.,et al.J. Biol. Chem. 275:22313-22323(2000).
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