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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   LTK Antibody (aa800-864)   

LTK Antibody (aa800-864)

Rabbit Polyclonal Antibody

     
  • IHC - LTK Antibody (aa800-864) ALS12093
    Anti-LTK antibody IHC of human colon.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P29376
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 92kDa
Dilution IHC-P (10 µg/ml), WB (0.5-2 µg/ml),
Additional Information
Gene ID 4058
Other Names Leukocyte tyrosine kinase receptor, 2.7.10.1, Protein tyrosine kinase 1, LTK, TYK1
Target/Specificity A portion of amino acids 800-864 of human LTK was used as the immunogen.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsLTK Antibody (aa800-864) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LTK
Synonyms TYK1
Function Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in non-hematopoietic cell lines and T- and B-cell lines.
Research Areas
Citations (0)

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Background

Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.

References

Toyoshima H.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:5404-5408(1993).
Krolewski J.J.,et al.EMBO J. 10:2911-2919(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12093
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