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>   home   >   Products   >   Primary Antibodies   >   MBD3 Antibody (aa215-230, clone 106B691)   

MBD3 Antibody (aa215-230, clone 106B691)

Mouse Monoclonal Antibody

     
  • IHC - MBD3 Antibody (aa215-230, clone 106B691) ALS12095
    Anti-MBD3 antibody IHC of human kidney.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O95983
Reactivity Human, Pig, Chicken, Horse, Xenopus, Bovine, Dog
Host Mouse
Clonality Monoclonal
Clone Names 106B691
Calculated MW 33kDa
Dilution IHC-P (10 µg/ml), WB (2 µg/ml),
Additional Information
Gene ID 53615
Other Names Methyl-CpG-binding domain protein 3, Methyl-CpG-binding protein MBD3, MBD3
Target/Specificity Amino acids215-230 (CKAFMVTDEDIRKQEE) of humanMBD3 protein were used as the immunogen.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsMBD3 Antibody (aa215-230, clone 106B691) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MBD3
Function Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases.
Cellular Location Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes
Citations (0)

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Background

Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself (PubMed:12124384). Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases.

References

Hendrich B.,et al.Mol. Cell. Biol. 18:6538-6547(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Tatematsu K.,et al.Genes Cells 5:677-688(2000).

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$ 395.00
Cat# ALS12095
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