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SH3GLB1 / Bif / Endophilin B1 Antibody (clone 30A882.1.1)

Mouse Monoclonal Antibody

     
  • WB - SH3GLB1 / Bif / Endophilin B1 Antibody (clone 30A882.1.1) ALS12101
    Western blot analysis for Bif-1 using antibody at 2 µg/ml dilution against 10 µg of Jurkat cell...
  • IHC - SH3GLB1 / Bif / Endophilin B1 Antibody (clone 30A882.1.1) ALS12101
    Anti-SH3GLB1 / Bif-1 antibody IHC of human placenta.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9Y371
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 30A882.1.1
Calculated MW 41kDa
Dilution IHC-P (5 µg/ml), WB (1-2 µg/ml),
Additional Information
Gene ID 51100
Other Names Endophilin-B1, Bax-interacting factor 1, Bif-1, SH3 domain-containing GRB2-like protein B1, SH3GLB1, KIAA0491
Target/Specificity A full-length human Bif-1 recombinant protein was used as immunogen.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsSH3GLB1 / Bif / Endophilin B1 Antibody (clone 30A882.1.1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SH3GLB1
Synonyms KIAA0491
Function May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity).
Cellular Location Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane. Midbody. Note=Association with the Golgi apparatus depends on the cell type (By similarity). Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes (PubMed:17891140) {ECO:0000250, ECO:0000269|PubMed:17891140}
Tissue Location Highly expressed in heart, skeletal muscle, kidney and placenta. Detected at lower levels in brain, colon, thymus, spleen, liver, small intestine, lung and peripheral blood leukocytes.
Research Areas
Citations (0)

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Background

May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion.

References

Pierrat B.,et al.Genomics 71:222-234(2001).
Cuddeback S.M.,et al.J. Biol. Chem. 276:20559-20565(2001).
Modregger J.,et al.J. Biol. Chem. 278:4160-4167(2003).
Seki N.,et al.DNA Res. 4:345-349(1997).
Lai C.-H.,et al.Genome Res. 10:703-713(2000).

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Discontinued
Cat# ALS12101
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