|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat, Bovine, Dog|
|Dilution||IHC-P (10 µg/ml), WB (1-3 µg/ml),|
|Other Names||Serine/threonine-protein kinase SIK2, 126.96.36.199, Qin-induced kinase, Salt-inducible kinase 2, SIK-2, Serine/threonine-protein kinase SNF1-like kinase 2, SIK2|
|Target/Specificity||A portion of amino acids 100-150 of human SIK2 was used as the immunogen.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||SIK2 / SNF1LK2 Antibody (aa100-150) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.|
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Provided below are standard protocols that you may find useful for product applications.
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.
Lizcano J.M.,et al.EMBO J. 23:833-843(2004).
Nagase T.,et al.DNA Res. 5:277-286(1998).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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