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TNFRSF10A / DR4 Antibody (clone 32A1380)

Mouse Monoclonal Antibody

     
  • WB - TNFRSF10A / DR4 Antibody (clone 32A1380) ALS12114
    Western blot of 15 ug of total cell lysate from Daudi cells with anti-DR4 (antibody) at 2 ug/ml.
    detail
  • IHC - TNFRSF10A / DR4 Antibody (clone 32A1380) ALS12114
    Anti-TNFRSF10A / DR4 antibody IHC of human breast.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, Neut, Flo
Primary Accession O00220
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 32A1380  
Calculated MW 50kDa
Dilution IHC-P (5 µg/ml), WB (2-4 µg/ml),
Additional Information
Gene ID 8797
Other Names Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1, CD261, TNFRSF10A, APO2, DR4, TRAILR1
Target/Specificity A peptide corresponding to amino acid 1 to 20 of human DR4 mature protein.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsTNFRSF10A / DR4 Antibody (clone 32A1380) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFRSF10A
Synonyms APO2, DR4, TRAILR1
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF- kappa-B (PubMed:9430227).
Cellular Location Cell membrane; Single-pass type I membrane protein. Membrane raft. Cytoplasm, cytosol. Note=Palmitoylation is required for association with membranes.
Tissue Location Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K- 562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells
Research Areas
Citations (0)
citation

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Background

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.

References

Pan G.,et al.Science 276:111-113(1997).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Livingston R.J.,et al.Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
Nusbaum C.,et al.Nature 439:331-335(2006).

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Discontinued
Cat# ALS12114
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