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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TNFRSF10B / Killer / DR5 Antibody (aa388-407)   

TNFRSF10B / Killer / DR5 Antibody (aa388-407)

Rabbit Polyclonal Antibody

     
  • WB - TNFRSF10B / Killer / DR5 Antibody (aa388-407) ALS12115
    Western blot of 20 ug of whole cell lysates from HL60 cells with anti-DR5 at 5 ug/ml?dilution.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, ICC, Flo
Primary Accession O14763
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 48kDa
Dilution ICC, IHC-P (10 µg/ml), WB (1:500-1:1000)
Additional Information
Gene ID 8795
Other Names Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2, CD262, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Target/Specificity A peptide corresponding to amino acids 388 to 407 (isoform 2) of human DR5 precursor. The same sequence is found in isoform 1 at amino acids 417-436.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsTNFRSF10B / Killer / DR5 Antibody (aa388-407) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFRSF10B
Synonyms DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain
Research Areas
Citations (0)

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Background

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.

References

Screaton G.R.,et al.Curr. Biol. 7:693-696(1997).
Walczak H.,et al.EMBO J. 16:5386-5397(1997).
Schneider P.,et al.FEBS Lett. 416:329-334(1997).
Chaudhary P.M.,et al.Immunity 7:821-830(1997).
MacFarlane M.,et al.J. Biol. Chem. 272:25417-25420(1997).

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$ 395.00
Cat# ALS12115
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