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TNFRSF11A / RANK Antibody (aa326-616, clone 9A725)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, Flo |
|---|---|
| Primary Accession | Q9Y6Q6 |
| Reactivity | Human, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 9A725 |
| Calculated MW | 66kDa |
| Dilution | IHC-P (10 µg/ml), WB (1-2 µg/ml), |
| Gene ID | 8792 |
|---|---|
| Other Names | Tumor necrosis factor receptor superfamily member 11A, Osteoclast differentiation factor receptor, ODFR, Receptor activator of NF-KB, CD265, TNFRSF11A, RANK |
| Target/Specificity | A fusion protein containing amino acid residues 326-616 of human RANK was used as immunogen. This antibody recognizes an epitope located between amino acid residues 330-427 of human RANK. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | TNFRSF11A / RANK Antibody (aa326-616, clone 9A725) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNFRSF11A |
|---|---|
| Synonyms | RANK |
| Function | Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL- mediated osteoclastogenesis (PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity). |
| Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Membrane raft {ECO:0000250|UniProtKB:O35305} |
| Tissue Location | Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
References
Anderson D.M.,et al.Nature 390:175-179(1997).
Sirinian C.,et al.Gene 525:124-129(2013).
Papanastasiou A.D.,et al.Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Nakagawa N.,et al.Biochem. Biophys. Res. Commun. 253:395-400(1998).
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