|Application ||WB, IHC-P, Flo|
|Dilution||IHC-P (10 µg/ml), WB (1-2 µg/ml),|
|Other Names||Tumor necrosis factor receptor superfamily member 11A, Osteoclast differentiation factor receptor, ODFR, Receptor activator of NF-KB, CD265, TNFRSF11A, RANK|
|Target/Specificity||A fusion protein containing amino acid residues 326-616 of human RANK was used as immunogen. This antibody recognizes an epitope located between amino acid residues 330-427 of human RANK.|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||TNFRSF11A / RANK Antibody (aa326-616, clone 9A725) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
Anderson D.M.,et al.Nature 390:175-179(1997).
Sirinian C.,et al.Gene 525:124-129(2013).
Papanastasiou A.D.,et al.Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Nakagawa N.,et al.Biochem. Biophys. Res. Commun. 253:395-400(1998).
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