TNFRSF11A / RANK Antibody (aa603-613)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q9Y6Q6 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 66kDa |
Dilution | IHC-P (10 µg/ml), WB (1-3 µg/ml), |
Gene ID | 8792 |
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Other Names | Tumor necrosis factor receptor superfamily member 11A, Osteoclast differentiation factor receptor, ODFR, Receptor activator of NF-KB, CD265, TNFRSF11A, RANK |
Target/Specificity | A synthetic peptide corresponding to amino acid residues 603-613 of human RANK. Genbank accession number: NP_003830. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | TNFRSF11A / RANK Antibody (aa603-613) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TNFRSF11A |
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Synonyms | RANK |
Function | Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL- mediated osteoclastogenesis (PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (By similarity). Involved in the regulation of interactions between T-cells and dendritic cells (By similarity). |
Cellular Location | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Membrane raft {ECO:0000250|UniProtKB:O35305} |
Tissue Location | Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
References
Anderson D.M.,et al.Nature 390:175-179(1997).
Sirinian C.,et al.Gene 525:124-129(2013).
Papanastasiou A.D.,et al.Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Nakagawa N.,et al.Biochem. Biophys. Res. Commun. 253:395-400(1998).
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