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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Osteoprotegerin / OPG Antibody (aa20-37, clone 98A1071)   

Osteoprotegerin / OPG Antibody (aa20-37, clone 98A1071)

Mouse Monoclonal Antibody

     
  • IHC - Osteoprotegerin / OPG Antibody (aa20-37, clone 98A1071) ALS12119
    Anti-Osteoprotegerin antibody IHC of human heart.
  • IHC - Osteoprotegerin / OPG Antibody (aa20-37, clone 98A1071) ALS12119
    Anti-Osteoprotegerin antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O00300
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 98A1071
Calculated MW 46kDa
Dilution IHC-P (5 µg/ml)
Additional Information
Gene ID 4982
Other Names Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin, TNFRSF11B, OCIF, OPG
Target/Specificity A peptide corresponding to the amino acids 20-37 TQETFPPKYLHYDEETSH of human OPG was used to immunize mice. The specificity was tested on recombinant OPG by western blot analysis.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsOsteoprotegerin / OPG Antibody (aa20-37, clone 98A1071) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFRSF11B
Synonyms OCIF, OPG
Function Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Cellular Location Secreted.
Tissue Location Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung
Research Areas
Citations (0)

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Background

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.

References

Simonet W.S.,et al.Cell 89:309-319(1997).
Yasuda H.,et al.Endocrinology 139:1329-1337(1998).
Morinaga T.,et al.Eur. J. Biochem. 254:685-691(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS12119
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