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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TNIP2 / ABIN-2 Antibody   

TNIP2 / ABIN-2 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - TNIP2 / ABIN-2 Antibody ALS12123
    Anti-TNIP2 antibody IHC of human brain cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q8NFZ5
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 49kDa
Dilution IHC-P (5 µg/ml), WB (0.5-2 µg/ml),
Additional Information
Gene ID 79155
Other Names TNFAIP3-interacting protein 2, A20-binding inhibitor of NF-kappa-B activation 2, ABIN-2, Fetal liver LKB1-interacting protein, TNIP2 {ECO:0000312|EMBL:EAW82514.1}
Target/Specificity Synthetic peptides of human ABIN-2. It cross-reacts with mouse ABIN-2.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsTNIP2 / ABIN-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNIP2 {ECO:0000312|EMBL:EAW82514.1}
Function Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
Cellular Location Cytoplasm. Nucleus
Tissue Location Ubiquitously expressed in all tissues examined.
Research Areas
Citations (0)

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Background

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.

References

Van Huffel S.C.,et al.J. Biol. Chem. 276:30216-30223(2001).
Liu W.-K.,et al.J. Biomed. Sci. 10:242-252(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).

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$ 395.00
Cat# ALS12123
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