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TP73 / p73 Antibody (aa75-125)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | O15350 |
| Reactivity | Human, Mouse, Rat, Hamster, Monkey, Bovine, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 70kDa |
| Dilution | IHC-P (5 µg/ml), WB (1-3 µg/ml), |
| Gene ID | 7161 |
|---|---|
| Other Names | Tumor protein p73, p53-like transcription factor, p53-related protein, TP73, P73 |
| Target/Specificity | A portion of amino acids 75-125 of human p73 protein was used as the immunogen. |
| Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Precautions | TP73 / p73 Antibody (aa75-125) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TP73 |
|---|---|
| Synonyms | P73 |
| Function | Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761). |
| Cellular Location | Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage |
| Tissue Location | Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas Highly expressed in fetal tissue. Expressed in the respiratory epithelium (PubMed:34077761). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.
References
Kaghad M.,et al.Cell 90:809-819(1997).
Mai M.,et al.Genomics 51:359-363(1998).
De Laurenzi V.,et al.J. Exp. Med. 188:1763-1768(1998).
De Laurenzi V.,et al.Cell Death Differ. 6:389-390(1999).
Yoshikawa H.,et al.Oncogene 18:3415-3421(1999).
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