TRDMT1 / DNMT2 Antibody (clone 102B1259.2)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | O14717 |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Clone Names | 102B1259.2 |
Calculated MW | 45kDa |
Dilution | IHC-P (5 µg/ml), WB (1-3 µg/ml), |
Gene ID | 1787 |
---|---|
Other Names | tRNA (cytosine(38)-C(5))-methyltransferase, 2.1.1.204, DNA (cytosine-5)-methyltransferase-like protein 2, Dnmt2, DNA methyltransferase homolog HsaIIP, DNA MTase homolog HsaIIP, M.HsaIIP, PuMet, TRDMT1, DNMT2 |
Target/Specificity | Synthetic peptides corresponding to mouse Dnmt2. |
Reconstitution & Storage | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
Precautions | TRDMT1 / DNMT2 Antibody (clone 102B1259.2) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TRDMT1 |
---|---|
Synonyms | DNMT2 {ECO:0000303|PubMed:16424344} |
Function | Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp) (PubMed:16424344). Has higher activity on tRNA(Asp) modified with queuosine at position 34 (PubMed:30093495). |
Cellular Location | Cytoplasm. |
Tissue Location | Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes |
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Provided below are standard protocols that you may find useful for product applications.
Background
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
References
Yoder J.A.,et al.Hum. Mol. Genet. 7:279-284(1998).
Van den Wyngaert I.,et al.FEBS Lett. 426:283-289(1998).
Okano M.,et al.Nucleic Acids Res. 26:2536-2540(1998).
Deloukas P.,et al.Nature 429:375-381(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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