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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   RNF216 / TRIAD3 Antibody (aa350-400)   

RNF216 / TRIAD3 Antibody (aa350-400)

Rabbit Polyclonal Antibody

     
  • IHC - RNF216 / TRIAD3 Antibody (aa350-400) ALS12129
    Anti-RNF216 / TRIAD3 antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession Q9NWF9
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 99kDa
Dilution IHC-P (5 µg/ml), WB (1-3 µg/ml),
Additional Information
Gene ID 54476
Other Names E3 ubiquitin-protein ligase RNF216, 6.3.2.-, RING finger protein 216, Triad domain-containing protein 3, Ubiquitin-conjugating enzyme 7-interacting protein 1, Zinc finger protein inhibiting NF-kappa-B, RNF216, TRIAD3, UBCE7IP1, ZIN
Target/Specificity KLH-conjugated synthetic peptide corresponding to a portion of human TRIAD3 between amino acids 350-400.
Reconstitution & Storage Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
PrecautionsRNF216 / TRIAD3 Antibody (aa350-400) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF216
Synonyms TRIAD3, UBCE7IP1, ZIN
Function Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.
Cellular Location Cytoplasm.
Tissue Location Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes
Research Areas
Citations (0)

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Background

Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.

References

Chen D.,et al.J. Biol. Chem. 277:15985-15991(2002).
Chuang T.-H.,et al.Nat. Immunol. 5:495-502(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Hillier L.W.,et al.Nature 424:157-164(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 395.00
Cat# ALS12129
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