|Application ||WB, IHC-P, IP|
|Other Names||Nitric oxide synthase, endothelial, 22.214.171.124, Constitutive NOS, cNOS, EC-NOS, Endothelial NOS, eNOS, NOS type III, NOSIII, NOS3|
|Target/Specificity||Human eNOS amino acids 1186-1203 (RGAVPWAFDPPGSDTNSP)1,2,3|
|Reconstitution & Storage||Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.|
|Precautions||NOS3 / eNOS Antibody (aa1186-1203) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.|
|Cellular Location||Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity|
|Tissue Location||Platelets, placenta, liver and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Janssens S.P.,et al.J. Biol. Chem. 267:14519-14522(1992).
Janssens S.P.,et al.J. Biol. Chem. 267:22694-22694(1992).
Marsden P.A.,et al.FEBS Lett. 307:287-293(1992).
Marsden P.A.,et al.J. Biol. Chem. 268:17478-17488(1993).
Nadaud S.A.,et al.Biochem. Biophys. Res. Commun. 198:1027-1033(1994).
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