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MYO5B / Myosin VB Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - MYO5B / Myosin VB Antibody (N-Terminus) ALS12143
    Anti-MYO5B antibody IHC of human skeletal muscle.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9ULV0
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 214kDa
Dilution ELISA (1 µg/ml), IHC-P (2.5 µg/ml), WB (1 µg/ml)
Additional Information
Gene ID 4645
Other Names Unconventional myosin-Vb, MYO5B, KIAA1119
Target/Specificity Synthetic peptide corresponding to N-terminal residues of human Myosin-5B (Myosin Vb).
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsMYO5B / Myosin VB Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MYO5B
Synonyms KIAA1119
Function May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:P70569}.
Research Areas
Citations (0)

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Background

May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis.

References

Hirosawa M.,et al.DNA Res. 6:329-336(1999).
Ohara O.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Yamakawa H.,et al.Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
Nusbaum C.,et al.Nature 437:551-555(2005).

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$ 395.00
Cat# ALS12143
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