|Application ||WB, IHC-P, E|
|Reactivity||Human, Rat, Hamster, Monkey, Pig, Horse|
|Dilution||ELISA (1:32000), IHC-P (5 µg/ml), WB (0.1-0.3 µg/ml)|
|Other Names||Receptor tyrosine-protein kinase erbB-3, 220.127.116.11, Proto-oncogene-like protein c-ErbB-3, Tyrosine kinase-type cell surface receptor HER3, ERBB3, HER3|
|Target/Specificity||Human ERBB3. This antibody is expected to recognise isoform 1 (NP_001973.2) only.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||ERBB3 / HER3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Epithelial tissues and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5.
Kraus M.H.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:9193-9197(1989).
Plowman G.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:4905-4909(1990).
Katoh M.,et al.Biochem. Biophys. Res. Commun. 192:1189-1197(1993).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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