|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Dilution||IHC-P (2.5 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||NT-3 growth factor receptor, 22.214.171.124, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, NTRK3, TRKC|
|Target/Specificity||Recognizes rat TrkC, Mr 145kD and an additional band at ~100kD. Species cross reactivity human and mouse.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||NTRK3 / TRKC Antibody (aa1-429) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for neurotrophin-3 (NT-3). This is a tyrosine- protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
McGregor L.M.,et al.Genomics 22:267-272(1994).
Shelton D.L.,et al.J. Neurosci. 15:477-491(1995).
Ichaso N.,et al.Oncogene 17:1871-1875(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
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