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TNFRSF1A / TNFR1 Antibody

Rabbit Polyclonal Antibody

     
  • IHC - TNFRSF1A / TNFR1 Antibody ALS12169
    Anti-TNFR1 antibody IHC of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P19438
Reactivity Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 50kDa
Dilution IHC-P (2.5 µg/ml)
Additional Information
Gene ID 7132
Other Names Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55, p60, CD120a, Tumor necrosis factor receptor superfamily member 1A, membrane form, Tumor necrosis factor-binding protein 1, TBPI, TNFRSF1A, TNFAR, TNFR1
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsTNFRSF1A / TNFR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFRSF1A
Synonyms TNFAR, TNFR1
Function Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Cellular Location Cell membrane; Single-pass type I membrane protein Golgi apparatus membrane; Single- pass type I membrane protein Secreted. Note=A secreted form is produced through proteolytic processing
Research Areas
Citations (0)

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Background

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

References

Loetscher H.,et al.Cell 61:351-359(1990).
Schall T.J.,et al.Cell 61:361-370(1990).
Himmler A.,et al.DNA Cell Biol. 9:705-715(1990).
Nophar Y.,et al.EMBO J. 9:3269-3278(1990).
Gray P.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7380-7384(1990).

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$ 395.00
Cat# ALS12169
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