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JUP/CTNNG/Junction Plakoglobin Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P14923 |
| Reactivity | Human, Mouse, Rabbit, Hamster, Monkey, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 82kDa |
| Dilution | ELISA (1:32000), IHC-P (5 µg/ml), WB (0.2-1 µg/ml) |
| Gene ID | 3728 |
|---|---|
| Other Names | Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3, JUP, CTNNG, DP3 |
| Target/Specificity | Human JUP / Gamma Catenin. This antibody is expected to recognise both reported isoforms, as represented by NP_002221.1 and NP_068831.1. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | JUP/CTNNG/Junction Plakoglobin Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | JUP (HGNC:6207) |
|---|---|
| Function | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). |
| Cellular Location | Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane-associated form |
| Tissue Location | Expressed in the heart (at protein level). |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).
References
Franke W.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:4027-4031(1989).
Zimbelmann R.,et al.Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
Whittock N.V.,et al.Exp. Dermatol. 9:323-326(2000).
Liang X.-J.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).
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