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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TLR7 Antibody (aa706-728)   

TLR7 Antibody (aa706-728)

Rabbit Polyclonal Antibody

     
  • WB - TLR7 Antibody (aa706-728) ALS12183
    Western blot of TLR7 in Raw cell lysate using antibody at 1 ug/ml.
  • IHC - TLR7 Antibody (aa706-728) ALS12183
    Anti-TLR7 antibody IHC of human small intestine.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IHC-Fr, Flo
Primary Accession Q9NYK1
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 121kDa
Dilution IHC-Fr, IHC-P (5 µg/ml), WB (1-3 µg/ml)
Additional Information
Gene ID 51284
Other Names Toll-like receptor 7, TLR7
Target/Specificity KLH-conjugated synthetic peptide corresponding to amino acids 706-728 of human TLR7. It will cross-react with mouse TLR7. In human Ramos cells, additional bands are seen.
Reconstitution & Storage +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsTLR7 Antibody (aa706-728) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLR7
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P58681}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P58681}. Endosome {ECO:0000250|UniProtKB:P58681}. Lysosome {ECO:0000250|UniProtKB:P58681}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P58681}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist {ECO:0000250|UniProtKB:P58681}
Tissue Location Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells
Volume 50 µl
Research Areas
Citations (0)

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Background

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

References

Du X.,et al.Eur. Cytokine Netw. 11:362-371(2000).
Chuang T.-H.,et al.Eur. Cytokine Netw. 11:372-378(2000).
Georgel P.,et al.PLoS ONE 4:E7803-E7803(2009).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Gantier M.P.,et al.J. Immunol. 180:2117-2124(2008).

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$ 395.00
Cat# ALS12183
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