|Application ||WB, IHC-P|
|Reactivity||Human, Mouse, Monkey, Pig, Horse, Bovine, Dog|
|Dilution||IHC-P (5 µg/ml), WB (0.5-2 µg/ml),|
|Other Names||Parathyroid hormone/parathyroid hormone-related peptide receptor, PTH/PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R, PTHR, PTHR1|
|Target/Specificity||Recognizes human PTH/PTHrP receptor, MW 80kD, and the receptor dimer, Mr 160kD. A faint nonspecific band at 110kD is also detected. This antibody does not detect the PTH2 receptor.|
|Reconstitution & Storage||Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||PTHR / PTHR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in most tissues. Most abundant in kidney, bone and liver.|
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Provided below are standard protocols that you may find useful for product applications.
This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
Schipani E.,et al.Endocrinology 132:2157-2165(1993).
Schneider H.,et al.Eur. J. Pharmacol. 246:149-155(1993).
Schipani E.,et al.J. Clin. Endocrinol. Metab. 80:1611-1621(1995).
Levine M.A.,et al.Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
King M.M.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
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