CED6 / GULP1 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
---|---|
Primary Accession | Q9UBP9 |
Reactivity | Human, Mouse, Rat, Rabbit, Hamster, Monkey, Pig, Chicken, Bovine, Dog |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 34kDa |
Dilution | ELISA (1:64000), IHC-P (5 µg/ml), WB (0.2-0.6 µg/ml) |
Gene ID | 51454 |
---|---|
Other Names | PTB domain-containing engulfment adapter protein 1, Cell death protein 6 homolog, PTB domain adapter protein CED-6, Protein GULP, GULP1, CED6, GULP |
Target/Specificity | Human GULP1 / CED6. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | CED6 / GULP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GULP1 |
---|---|
Synonyms | CED6, GULP |
Function | May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. |
Cellular Location | Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes |
Tissue Location | Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary. |
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Background
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
References
Liu Q.A.,et al.Curr. Biol. 9:1347-1350(1999).
Smits E.,et al.Curr. Biol. 9:1351-1354(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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