|Application ||IHC-P, E|
|Reactivity||Human, Rabbit, Hamster, Monkey|
|Dilution||ELISA (1:32000), IHC-P (5 µg/ml),|
|Other Names||Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3, AGAP-3, CRAM-associated GTPase, CRAG, Centaurin-gamma-3, Cnt-g3, MR1-interacting protein, MRIP-1, AGAP3, CENTG3|
|Target/Specificity||Human AGAP3 / CENTG3.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||AGAP3 / CENTG3 / MRIP-1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.|
|Cellular Location||Cytoplasm. Note=In cells upon oxidative stress or in brains of Machado-Joseph disease patients, translocates to PML nuclear bodies|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.
Xia C.,et al.Mol. Cell. Biol. 23:2476-2488(2003).
Hong W.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 424:157-164(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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