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PARD6A / PAR6 Antibody (C-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q9NPB6 |
| Reactivity | Human |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 37kDa |
| Dilution | ELISA (1:8000), IHC-P (5 µg/ml), |
| Gene ID | 50855 |
|---|---|
| Other Names | Partitioning defective 6 homolog alpha, PAR-6, PAR-6 alpha, PAR-6A, PAR6C, Tax interaction protein 40, TIP-40, PARD6A, PAR6A |
| Target/Specificity | Human PARD6A / PAR6. This antibody is expected to recognise both reported isoforms (NP_058644.1; NP_001032358.1). |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | PARD6A / PAR6 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PARD6A |
|---|---|
| Synonyms | PAR6A |
| Function | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). |
| Cellular Location | Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions. Recruited to the centrosome by a microtubule and dynein-dynactin-dependent mechanism |
| Tissue Location | Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta |
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Provided below are standard protocols that you may find useful for product applications.
Background
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
References
Johansson A.-S.,et al.J. Cell Sci. 113:3267-3275(2000).
Qiu R.-G.,et al.Curr. Biol. 10:697-707(2000).
Joberty G.,et al.Nat. Cell Biol. 2:531-539(2000).
Suzuki A.,et al.J. Cell Biol. 152:1183-1196(2001).
Noda Y.,et al.Genes Cells 6:107-119(2001).
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