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PARD6A / PAR6 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - PARD6A / PAR6 Antibody (C-Terminus) ALS12200
    Anti-PARD6A / PAR6 antibody IHC of human heart.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q9NPB6
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 37kDa
Dilution ELISA (1:8000), IHC-P (5 µg/ml),
Additional Information
Gene ID 50855
Other Names Partitioning defective 6 homolog alpha, PAR-6, PAR-6 alpha, PAR-6A, PAR6C, Tax interaction protein 40, TIP-40, PARD6A, PAR6A
Target/Specificity Human PARD6A / PAR6. This antibody is expected to recognise both reported isoforms (NP_058644.1; NP_001032358.1).
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsPARD6A / PAR6 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PARD6A
Synonyms PAR6A
Function Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959).
Cellular Location Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions. Recruited to the centrosome by a microtubule and dynein-dynactin-dependent mechanism
Tissue Location Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta
Research Areas
Citations (0)

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Background

Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

References

Johansson A.-S.,et al.J. Cell Sci. 113:3267-3275(2000).
Qiu R.-G.,et al.Curr. Biol. 10:697-707(2000).
Joberty G.,et al.Nat. Cell Biol. 2:531-539(2000).
Suzuki A.,et al.J. Cell Biol. 152:1183-1196(2001).
Noda Y.,et al.Genes Cells 6:107-119(2001).

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$ 395.00
Cat# ALS12200
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