|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:16000), IHC-P (5 µg/ml),|
|Other Names||Intraflagellar transport protein 74 homolog, Capillary morphogenesis gene 1 protein, CMG-1, Coiled-coil domain-containing protein 2, IFT74, CCDC2, CMG1|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||IFT74 / CCDC2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.|
|Cellular Location||Cell projection, cilium. Cytoplasmic vesicle. Note=Localizes along primary cilia at interphase and around the basal body/centriole at interphase and mitosis|
|Tissue Location||Highly expressed in adult and fetal kidney and expressed at lower level in adult heart, placenta, lung, liver and pancreas, and in fetal heart, lung and liver. Little to no expression was detected in adult brain and skeletal muscle or in fetal brain, thymus and spleen.|
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Provided below are standard protocols that you may find useful for product applications.
Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis.
Bell S.E.,et al.J. Cell Sci. 114:2755-2773(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Li W.B.,et al.Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
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