|Application ||WB, IHC-P, E|
|Dilution||ELISA (1:32000), IHC-P (5 µg/ml), WB (1:32000)|
|Other Names||Aldo-keto reductase family 1 member C3, 1.-.-.-, 17-beta-hydroxysteroid dehydrogenase type 5, 17-beta-HSD 5, 3-alpha-HSD type II, brain, 3-alpha-hydroxysteroid dehydrogenase type 2, 3-alpha-HSD type 2, 18.104.22.1687, Chlordecone reductase homolog HAKRb, Dihydrodiol dehydrogenase 3, DD-3, DD3, Dihydrodiol dehydrogenase type I, HA1753, Indanol dehydrogenase, 22.214.171.124, Prostaglandin F synthase, PGFS, 126.96.36.199, Testosterone 17-beta-dehydrogenase 5, 188.8.131.52, 184.108.40.206, Trans-1, 2-dihydrobenzene-1, 2-diol dehydrogenase, 220.127.116.11, AKR1C3, DDH1, HSD17B5, KIAA0119, PGFS|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||DDX / AKR1C3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DDH1, HSD17B5, KIAA0119, PGFS|
|Function||Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.|
|Tissue Location||Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.|
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Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta- PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
Qin K.-N.,et al.J. Steroid Biochem. Mol. Biol. 46:673-679(1993).
Khanna M.,et al.J. Biol. Chem. 270:20162-20168(1995).
Khanna M.,et al.J. Steroid Biochem. Mol. Biol. 53:41-46(1995).
Lin H.-K.,et al.Mol. Endocrinol. 11:1971-1984(1997).
Suzuki-Yamamoto T.,et al.FEBS Lett. 462:335-340(1999).
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