|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat, Monkey, Pig, Chicken, Horse, Bovine, Dog|
|Dilution||ELISA (1:16000), IHC-P (5 µg/ml), WB (1:16000)|
|Other Names||Exocyst complex component 7, Exocyst complex component Exo70, EXOC7, EXO70, KIAA1067|
|Target/Specificity||Human EXOC7. This antibody is expected to recognise all five reported isoforms (NP_001013861.1; NP_056034.2; NP_001138769.1; NP_001138771.1; NP_001138770.1).|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||EXOC7 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ.|
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Provided below are standard protocols that you may find useful for product applications.
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion (By similarity).
Dellago H.,et al.Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
Kikuno R.,et al.DNA Res. 6:197-205(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Zody M.C.,et al.Nature 440:1045-1049(2006).
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