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S100A4 / FSP1 Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - S100A4 / FSP1 Antibody (C-Terminus) ALS12237
    Anti-S100A4 antibody IHC of human uterus, vessel.
    detail
  • IHC - S100A4 / FSP1 Antibody (C-Terminus) ALS12237
    Anti-S100A4 antibody IHC of human small intestine.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P26447
Reactivity Human, Rabbit, Pig, Bovine, Dog, Horse
Host Goat
Clonality Polyclonal
Calculated MW 12kDa
Dilution ELISA (1:128000), IHC-P (2.5-5 µg/ml), WB (0.03-0.1 µg/ml)
Additional Information
Gene ID 6275
Other Names Protein S100-A4, Calvasculin, Metastasin, Placental calcium-binding protein, Protein Mts1, S100 calcium-binding protein A4, S100A4, CAPL, MTS1
Target/Specificity Human S100A4 / FSP1. Both variants (NP_002952.1; NP_062427.1) represent identical protein.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsS100A4 / FSP1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name S100A4
Synonyms CAPL, MTS1
Function Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197). Within the extracellular space, stimulates cytokine production including granulocyte colony- stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:30713770, PubMed:26654597).
Cellular Location Secreted. Nucleus Cytoplasm {ECO:0000250|UniProtKB:P07091}
Tissue Location Ubiquitously expressed.
Volume Array
Research Areas
Citations (0)
citation

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References

Engelkamp D.,et al.Biochemistry 31:10258-10264(1992).
Engelkamp D.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:6547-6551(1993).
Tulchinsky E.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:9146-9150(1992).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 585.00
Cat# ALS12237
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