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CLIC4 Antibody (N-Terminus)

Goat Polyclonal Antibody

     
  • WB - CLIC4 Antibody (N-Terminus) ALS12239
    Antibody (0.1 ug/ml) staining of human kidney lysate (35 ug protein in RIPA buffer).
    detail
  • IHC - CLIC4 Antibody (N-Terminus) ALS12239
    Anti-CLIC4 antibody IHC of human heart.
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9Y696
Reactivity Human, Mouse, Rat, Monkey
Host Goat
Clonality Polyclonal
Calculated MW 29kDa
Dilution ELISA (1:64000), IF (5 µg/ml), IHC-P (5 µg/ml), WB (0.1-0.3 µg/ml) ,
Additional Information
Gene ID 25932
Other Names Chloride intracellular channel protein 4, Intracellular chloride ion channel protein p64H1, CLIC4
Target/Specificity Human CLIC4.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCLIC4 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLIC4
Function Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus. Cell membrane; Single-pass membrane protein. Mitochondrion {ECO:0000250|UniProtKB:Q9Z0W7}. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Might not be present in the nucleus of cardiac cells. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:14569596}
Tissue Location Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.
Research Areas
Citations (0)
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Background

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).

References

Edwards J.C.,et al.Am. J. Physiol. 276:F398-F408(1999).
Chuang J.Z.,et al.J. Neurosci. 19:2919-2928(1999).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Bienvenut W.V.,et al.Submitted (FEB-2006) to UniProtKB.
Berryman M.,et al.Mol. Biol. Cell 11:1509-1521(2000).

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Discontinued
Cat# ALS12239
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