CLIC4 Antibody (N-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q9Y696 |
Reactivity | Human, Mouse, Rat, Monkey |
Host | Goat |
Clonality | Polyclonal |
Calculated MW | 29kDa |
Dilution | ELISA (1:64000), IF (5 µg/ml), IHC-P (5 µg/ml), WB (0.1-0.3 µg/ml) , |
Gene ID | 25932 |
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Other Names | Chloride intracellular channel protein 4, Intracellular chloride ion channel protein p64H1, CLIC4 |
Target/Specificity | Human CLIC4. |
Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
Precautions | CLIC4 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CLIC4 |
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Function | Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). |
Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus. Cell membrane; Single-pass membrane protein. Mitochondrion {ECO:0000250|UniProtKB:Q9Z0W7}. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Might not be present in the nucleus of cardiac cells. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:14569596} |
Tissue Location | Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. |
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Background
Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
References
Edwards J.C.,et al.Am. J. Physiol. 276:F398-F408(1999).
Chuang J.Z.,et al.J. Neurosci. 19:2919-2928(1999).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Bienvenut W.V.,et al.Submitted (FEB-2006) to UniProtKB.
Berryman M.,et al.Mol. Biol. Cell 11:1509-1521(2000).
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