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CBX1 / HP1 Beta Antibody (Internal)

Goat Polyclonal Antibody

     
  • WB - CBX1 / HP1 Beta Antibody (Internal) ALS12245
    Antibody (0.3 ug/ml) staining of A431 lysate (35 ug protein in RIPA buffer).
  • IHC - CBX1 / HP1 Beta Antibody (Internal) ALS12245
    Anti-CBX1 antibody IHC of human placenta.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P83916
Reactivity Human, Mouse, Hamster, Monkey, Pig, Horse, Bovine, Dog
Host Goat
Clonality Polyclonal
Calculated MW 21kDa
Dilution ELISA (1:32000), IHC-P (2.5 µg/ml), WB (1:32000)
Additional Information
Gene ID 10951
Other Names Chromobox protein homolog 1, HP1Hsbeta, Heterochromatin protein 1 homolog beta, HP1 beta, Heterochromatin protein p25, M31, Modifier 1 protein, p25beta, CBX1, CBX
Target/Specificity Human CBX1. Variants (NP_006798.1; NP_001120700.1) encode the same protein.
Reconstitution & Storage Store at -20°C. Minimize freezing and thawing.
PrecautionsCBX1 / HP1 Beta Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX1
Synonyms CBX
Function Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
Cellular Location Nucleus. Note=Unassociated with chromosomes during mitosis
Tissue Location Expressed in all adult and embryonic tissues.
Citations (0)

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Background

Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.

References

Furuta K.,et al.Chromosoma 106:11-19(1997).
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.
Minc E.,et al.Chromosoma 108:220-234(1999).
Aagaard L.,et al.EMBO J. 18:1923-1938(1999).
Hughes-Davies L.,et al.Cell 115:523-535(2003).

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$ 395.00
Cat# ALS12245
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