|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Hamster, Monkey, Pig, Horse, Bovine, Dog|
|Dilution||ELISA (1:32000), IHC-P (2.5 µg/ml), WB (1:32000)|
|Other Names||Chromobox protein homolog 1, HP1Hsbeta, Heterochromatin protein 1 homolog beta, HP1 beta, Heterochromatin protein p25, M31, Modifier 1 protein, p25beta, CBX1, CBX|
|Target/Specificity||Human CBX1. Variants (NP_006798.1; NP_001120700.1) encode the same protein.|
|Reconstitution & Storage||Store at -20°C. Minimize freezing and thawing.|
|Precautions||CBX1 / HP1 Beta Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.|
|Cellular Location||Nucleus. Note=Unassociated with chromosomes during mitosis|
|Tissue Location||Expressed in all adult and embryonic tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
Furuta K.,et al.Chromosoma 106:11-19(1997).
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.
Minc E.,et al.Chromosoma 108:220-234(1999).
Aagaard L.,et al.EMBO J. 18:1923-1938(1999).
Hughes-Davies L.,et al.Cell 115:523-535(2003).
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